Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice
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منابع مشابه
Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men.
BACKGROUND In sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower age-related risk. We determined the influence of regular aerobic exercise on the age-related decline in endothelium-dependent vasodilation. METHODS AND RESULTS In a cross-sectional study, 68 hea...
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Atherogenic lipoproteins can cause endothelial dysfunction in the initial stage of atherogenesis. In our study we examined 134 patients with defined hyperlipoproteinemia (non-HDL cholesterol>4.1 mmol/l or triglycerides>2.5 mmol/l or taking any of lipid lowering drugs)--94 men and 40 women. The subgroup of controls of comparable age contained 54 normolipidemic individuals--30 men and 24 women. P...
متن کاملAscorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans.
BACKGROUND Endothelium-dependent vasodilation is impaired in patients with insulin-dependent and non-insulin-dependent diabetes mellitus and restored by vitamin C administration, implicating a causative role for oxidant stress. Hyperglycemia per se attenuates endothelium-dependent vasodilation in healthy subjects. Accordingly, this study investigated whether impaired endothelium-dependent vasod...
متن کاملEnhanced endothelium-dependent vasodilation in Fabry disease.
BACKGROUND AND PURPOSE Fabry disease is an X-linked lysosomal storage disease secondary to deficiency of alpha-galactosidase A with resulting glycolipid accumulation, particularly globotriaosylceramide in arterial smooth muscle and endothelial cells. A systemic vasculopathy, including early-onset stroke, is prevalent without a clear pathogenesis. METHODS Seventeen normotensive and normocholes...
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BACKGROUND Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ's protection against ischemic episodes. The present study examines whether the AT1R blocker candesartan (1) has a beneficial effect on diabetes-induced alteration of pressure-induced vasodilation (PIV, a cutaneous physiological neurovascular mechanism which c...
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ژورنال
عنوان ژورنال: Vascular Pharmacology
سال: 2008
ISSN: 1537-1891
DOI: 10.1016/j.vph.2007.09.001